Outcomes of percutaneous coronary intervention for intermediate coronary artery disease guided by intravascular ultrasound or fractional flow reserve.
- Author:
Huihua ZUO
1
;
Qiang LIU
;
Zhiling ZHANG
;
Lili WANG
;
Jianxin WENG
;
Yi WEI
;
Xinlin LUO
;
Qiying CHEN
;
Qian CAO
Author Information
- Publication Type:Journal Article
- MeSH: Coronary Angiography; Coronary Artery Disease; surgery; Fractional Flow Reserve, Myocardial; Humans; Myocardial Infarction; Percutaneous Coronary Intervention
- From: Journal of Southern Medical University 2014;34(5):704-708
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the long-term clinical outcomes of fractional flow reserve (FFR)-guided versus intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) for intermediate coronary lesions.
METHODSA total of 226 patients with 293 intermediate coronary artery lesions (stenosis of 40%-70%) confirmed by coronary angiography were randomized into 3 groups to undergo PCI for a minimal lumen cross sectional area (MLA)<4 mm(2) (IVUS group, 98 lesions) or for a FFR<0.80 (FFR group, 101 lesions), or to receive standard medical treatment (medication group, 94 lesions). The primary outcome was major adverse cardiac events including death, myocardial infarction, and ischemia-driven target vessel revascularization at 1 year after the index procedure.
RESULTSThe baseline percent diameter stenosis and lesion length were similar between the 3 groups, but more patients in IVUS group than in FFR group received PCI (P<0.001). No significant difference was found in the incidence of major adverse cardiac events between the 3 groups (P=0.182).
CONCLUSIONBoth FFR- and IVUS-guided PCI strategy for intermediate coronary artery disease are associated with favorable outcomes, but IVUS-guided PCI based on the single index of MLA can increase the rate of revascularization therapy.