Role of Wnt/β-catenin signaling pathway in promoting tumorigenesis of hepatocellular carcinoma.
- Author:
Lianghai XIE
1
;
Han JIANG
;
Fusheng WU
Author Information
1. Beilun District TCM hospital, Ningbo 315800, China.
- Publication Type:Journal Article
- MeSH:
Carcinogenesis;
Carcinoma, Hepatocellular;
Humans;
Liver Neoplasms;
Wnt Proteins;
Wnt Signaling Pathway;
beta Catenin
- From:
Journal of Southern Medical University
2014;34(6):913-917
- CountryChina
- Language:Chinese
-
Abstract:
Wnt/β-catenin signaling pathway has a close relationship with cancer and is abnormally activated in many human cancers. Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide, but the molecular mechanisms of HCC are still poorly understood. Current studies indicate that Wnt/β-catenin signaling pathway plays a key role in the development and progression of HCC. Validating the role and mechanism of Wnt/β-catenin signaling pathway in HCC will provide a theoretical basis for early diagnosis and treatment of HCC. In this review, we summarize the role of Wnt/β-catenin signaling pathway in HCC and the progress of current researches.
