Research on application of determination of MMP-13 in osteoarthritis.
- Author:
Wen-Xiao CHEN
;
Fang-Jun SHAN
;
Hong-Ting JIN
;
Ping-Er WANG
;
Lu-Wei XIAO
;
Pei-Jian TONG
- Publication Type:Journal Article
- MeSH:
Animals;
Collagen;
metabolism;
Humans;
Matrix Metalloproteinase 13;
analysis;
physiology;
Matrix Metalloproteinase Inhibitors;
therapeutic use;
Osteoarthritis;
drug therapy;
etiology
- From:
China Journal of Orthopaedics and Traumatology
2014;27(7):617-620
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis (OA) is a complex chronic progressive disease attacked by biological and mechanical factors and a result from the anabolic and catabolic imbalance in chondrocyte, subchondral bone and extracellular matrix(ECM). Etiology and pathological of OA are not yet entirely clear. The degradation and destruction of collagen II caused by matrix metalloproteinase -13 (MMP-13) is considered the core factor in the occurrence and development of OA. The research of MMP-13 inhibitor provide ideas and methods for the treatment of OA. In this article,the role and determination of MMP-13 in OA and the development prospect of MMP-13 inhibitor in the treatment of OA research progress were reviewed.
