Morphological diagnosis of endometrial intraepithelial neoplasia and expression of PTEN.
- Author:
Wei-Xun ZHOU
1
;
Zhi-Yong LIANG
;
Jie GAO
;
Tong-Hua LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Endometrioid; metabolism; pathology; Endometrial Hyperplasia; metabolism; pathology; Endometrial Neoplasms; metabolism; pathology; Female; Humans; Middle Aged; PTEN Phosphohydrolase; metabolism; Precancerous Conditions; metabolism; pathology; Young Adult
- From: Chinese Journal of Pathology 2009;38(6):393-396
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the diagnostic applications of endometrial intraepithelial neoplasia (EIN), and the expression of PTEN in endometrial lesions.
METHODSFifty-one cases of endometrial lesions were enrolled in this study. Using diagnostic criteria of EIN, the diagnosis were made and compared with the original results. Immunohistochemistry for PTEN was performed in all cases.
RESULTSTwo cases of simple hyperplasia originally diagnosed were reclassified as EIN. Three cases with atypia originally diagnosed showed no EIN pattern. PTEN deletion rates were 50.0%, 50.0%, 66.7% and 81.8% in proliferative endometrium, benign hyperplasia, EIN and endometrial carcinoma, respectively.
CONCLUSIONSDiagnosis of EIN is applicable and its morphology and diagnostic criteria are different from the classical one (WHO94) for endometrial hyperplasia. Detection of PTEN deletion by immunohistochemistry is useful in identifying EIN, but cannot be used as an ultimate confirming factor.
