Simultaneous qualitative and quantitative dosage of Dextromethorphan hydrobromide, Chlorpheniramine maleate, Guaiphenesine and Phenylpropanolamine hydrochloride in the mixture of antipyretic and analgesic drug with HPLC
- Author:
Hoa Thi Bui
- Publication Type:Journal Article
- Keywords:
drug
- MeSH:
Pharmaceutical Preparations;
Dextromethorphan;
Chlorpheniramine;
Analgesics, Non-Narcotic;
Analgesics
- From:Pharmaceutical Journal
1999;274(2):16-18
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
An HPLC method for simultaneous determination of Dextromethorphan hydrobromide, Clorpheniramine maleate, Guaiphenesin, and Phenylpropanolamine hydrochloride in tablets, capsules or in syrups is introduced. The chromatographic conditions are as follows: Column: Lichrosorb Si 60(250X 4 mm; 5mm); Mobile phase: Water: 0.001 M Ammonium Perchlorate methanolic solution pH6.7:20:80; Flow rate: 0.8 ml/min; UV- Detector at 254 nm. Experimental results showed that the method is accurate (er = 0.69 - 3.19%; recoveries: 98.7-101.9%).
