Relationship between primary ocular adnexal mucosa-associated lymphoid tissue lymphoma and eye infection.
- Author:
Dan-dan ZHANG
1
;
Hong-gang LIU
;
Hai-yan LI
;
Zi-fen GAO
;
Xiao-ge ZHOU
;
Ha-si JIN
;
Li-na DONG
;
Jing ZHANG
;
Li-ping GONG
Author Information
- Publication Type:Journal Article
- MeSH: Adenovirus Infections, Human; virology; Adenoviruses, Human; genetics; isolation & purification; Chlamydia Infections; microbiology; Chlamydia trachomatis; genetics; isolation & purification; Chlamydophila Infections; microbiology; Chlamydophila pneumoniae; genetics; isolation & purification; Chlamydophila psittaci; genetics; isolation & purification; DNA, Bacterial; analysis; DNA, Viral; analysis; Eye Infections; microbiology; virology; Eye Neoplasms; microbiology; virology; Herpes Simplex; virology; Herpesvirus 1, Human; genetics; isolation & purification; Herpesvirus 2, Human; genetics; isolation & purification; Humans; Lymphoma, B-Cell, Marginal Zone; microbiology; virology; Psittacosis; microbiology
- From: Chinese Journal of Pathology 2009;38(8):513-518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the role of pathogenic microorganisms commonly associated with chronic eye disease, including Chlamydia psittaci, Chlamydia trachomatis, Chlamydia pneumoniae, herpes simplex virus (HSV) type 1 and type 2, and adenovirus type 8 and type 19, in the development of primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma in Chinese patients.
METHODSSixty-eight archival cases of primary ocular adnexal lymphoproliferative lesions, including 38 cases of MALT lymphoma, 3 cases of non-MALT lymphoma and 27 cases of chronic inflammation, were enrolled into the study. DNA was extracted from the paraffin-embedded tissue samples. The presence of DNA of C. psittaci, C. trachomatis, C. pneumoniae, HSV type 1, HSV type 2, adenovirus type 8 and adenovirus type 19 were analyzed by multiplex touchdown enzyme time-release polymerase chain reaction (TETR-PCR).
RESULTSAll of the specimens yielded PCR products of over 100 base pairs and were thus suitable for TETR-PCR screening of infectious agents. The prevalence of DNA of C. psittaci, C. trachomatis and adenovirus type 19 were 0 in MALT lymphoma, non-MALT lymphoma and chronic inflammation. There were 2 cases positive for C. pneumoniae DNA, amongst the 38 cases of MALT lymphoma studied (5.3%, 2/38). HSV type 1, HSV type 2 and adenovirus type 8 DNA was found in each of the 3 patients with chronic inflammation.
CONCLUSIONThe study indicates that C. psittaci, C. trachomatis, C. pneumoniae, HSV type 1, HSV type 2, adenovirus type 8 and adenovirus type 19 probably play little role in the pathogenesis of ocular adnexal MALT lymphoma in Chinese patients.
