Expression of CD147, matrix metalloproteinases and transforming growth factor beta1 in breast cancer.
- Author:
Song XUE
1
;
Shou-xin LI
;
Zheng-sheng WU
;
Xiao-nan WANG
;
Qiang WU
;
Feng YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Basigin; metabolism; Breast Neoplasms; metabolism; pathology; Carcinoma, Ductal, Breast; metabolism; pathology; Female; Fibroadenoma; metabolism; pathology; Follow-Up Studies; Humans; Lymphatic Metastasis; Matrix Metalloproteinase 2; metabolism; Matrix Metalloproteinase 9; metabolism; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Protein-Serine-Threonine Kinases; metabolism; Receptor, ErbB-2; metabolism; Receptors, Progesterone; metabolism; Receptors, Transforming Growth Factor beta; metabolism; Survival Rate; Transforming Growth Factor beta1; metabolism; Young Adult
- From: Chinese Journal of Pathology 2009;38(8):524-528
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of CD147, matrix metalloproteinase (MMP)-2, MMP-9, Transforming growth factor (TGFbeta1) and TGFbetaRI proteins and their relationships to breast cancer.
METHODSThe expression of CD147, MMP-2, MMP-9, TGFbeta1 and TGFbetaRI proteins was examined on tissue chips containing 160 cases of breast carcinomas by S-P immunohistochemical method.
RESULTSThe positive rates of CD147, MMP-2, MMP-9, TGFbeta1 and TGFbetaRI proteins were 87.5% (140/160), 96.9% (155/160), 95.0% (152/160), 73.7% (118/160) and 60.6% (97/160), respectively. The expression of CD147 was positively correlated with axillary lymph node metastasis, TNM staging and HER2 over expression (P < 0.01, P < 0.05 and P < 0.01, respectively), and inversely correlated with PR expression (P < 0.05). The patients' relapse-free survival was shorter in TGFbeta1-positive group than in TGFbeta1 negative group (P < 0.05). Both the expression of MMP-2 and MMP-9 were positively correlated with CD147 expression; and both the expression of TGFbeta1 and TGFbetaRI were positively correlated with CD147 expression (P < 0.01 and P < 0.05, respectively).
CONCLUSIONThe expression of CD147 is considered closely correlated with tumor invasion, metastasis and prognosis in breast cancer, and has also a close correlation with MMP-2, MMP-9, TGFbeta1 and TGFbetaRI expression.
