Immunohistochemical study using T-cell lymphoma antibody 1 and CD44 in diagnosis of Burkitt's lymphoma.
- Author:
Ruo-hong SHUI
1
;
Hong-fen LU
;
Xiong-zeng ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Burkitt Lymphoma; diagnosis; metabolism; pathology; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Hyaluronan Receptors; metabolism; Lymphoma, Large B-Cell, Diffuse; diagnosis; metabolism; pathology; Male; Middle Aged; Proto-Oncogene Proteins; metabolism; Young Adult
- From: Chinese Journal of Pathology 2009;38(11):745-748
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the values of immunohistochemistry using T-cell lymphoma antibody (TCL) 1 and CD44 in the diagnosis of Burkitt's lymphoma.
METHODSImmunohistochemical study for TCL1, CD44, CD10, bcl-2, bcl-6, c-myc and Ki-67 was performed on paraffin-embedded sections of lymphoma cases, including 25 cases of Burkitt's lymphoma and 25 cases of diffuse large B-cell lymphoma.
RESULTSBurkitt's lymphoma commonly expressed TCL1 (96%, 24 cases), CD10 (88%, 22 cases), bcl-6 and c-myc (92%, 23 cases). Only 1 case (4%) expressed CD44 and bcl-2. The Ki-67 proliferation index ranged from 95% to 100%. On the other hand, diffuse large B-cell lymphoma expressed CD44 (84%, 21 cases), CD10 (32%, 8 cases), bcl-6 (72%, 18 cases) and bcl-2 (72%, 18 cases). Four cases (16%) were weakly positive for TCL1. The staining for c-myc was all negative. The Ki-67 proliferation index ranged from 40% to 90%.
CONCLUSIONImmunohistochemical staining for TCL1 and CD44 is a useful ancillary tool in the pathologic diagnosis of Burkitt's lymphoma which is also helpful for the differential diagnosis from diffuse large B-cell lymphoma.
