Correlation of vasculogenic mimicry with clinicopathologic features and prognosis of ovarian carcinoma.
- Author:
Yan GAO
1
;
Xiu-lan ZHAO
;
Qiang GU
;
Jun-yan WANG
;
Shi-wu ZHANG
;
Dan-fang ZHANG
;
Xing-hui WANG
;
Nan ZHAO
;
Yu-tong GAO
;
Bao-cun SUN
Author Information
- Publication Type:Journal Article
- MeSH: Cadherins; metabolism; Carcinoma, Endometrioid; metabolism; pathology; Cystadenocarcinoma, Mucinous; metabolism; pathology; Cystadenocarcinoma, Serous; metabolism; pathology; Female; Humans; Matrix Metalloproteinase 2; metabolism; Matrix Metalloproteinase 9; metabolism; Middle Aged; Neoplasm Metastasis; Neovascularization, Pathologic; metabolism; pathology; Ovarian Neoplasms; metabolism; pathology; Survival Rate; Vascular Endothelial Growth Factor A; metabolism; beta Catenin; metabolism
- From: Chinese Journal of Pathology 2009;38(9):585-589
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the existence of vasculogenic mimicry (VM) in ovarian carcinoma and its correlationship with the clinicopathologic features and prognosis of the tumor.
METHODSA total of 84 ovarian carcinoma cases were collected with complete clinical and prognostic data. CD31 immunohistochemistry and PAS special stain were used to investigate VM in the tumor tissue. Immunohistochemical staining of VEGF, MMP-2, MMP-9, E-cadherin, beta-catenin, and Vimentin were used to explore the pathogenesis of VM.
RESULTSTotally 36 of 84 cases exhibited evidence of VM. FIGO classification, pathologic grades and histological types were significantly different between the VM and non-VM groups. Expression of VEGF, MMP-2, MMP-9, E-cadherin and beta-catenin were higher in the VM group than in the non-VM group. Kaplan-Meier survival curve analysis showed that cases of the VM group had a lower survival rate than that of the non-VM group (P = 0.04).
CONCLUSIONSVasculogenic mimicry exists in ovarian carcinoma. Ovarian carcinomas with a high grade malignancy have a high incidence of VM formation, a higher incidence of metastases and a lower survival rate. High expression of MMP-2 and MMP-9 may contribute to the formation of VM in the ovarian cancer.
