Progress of research between Helicobacter pylori infection and osteoporosis.
- Author:
Zhong-hai XU
1
;
Jun ZHANG
;
Di YANG
;
Jian-hua ZHANG
Author Information
1. Department of Orthopaedics, People's Hospital of Zhejiang Province, Hangzhou 310014, Zhejiang, China.
- Publication Type:Journal Article
- MeSH:
Helicobacter Infections;
complications;
drug therapy;
Helicobacter pylori;
Humans;
Osteoporosis;
etiology
- From:
China Journal of Orthopaedics and Traumatology
2011;24(11):966-968
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori (HP) is an infectious pathogen which can easily infringe gastric mucosa. If the body is infected by HP, it can release cytokines, such as TNF-alpha, IL-1 and IL-6. These cytokines can regulate the absorption and transformation of bone, promote the formation of osteoclast, and then cause localized or systemic osteoporosis. HP infection may decrease the level of estrogen and vitamin B12, which is considered as a risk factor for osteoporosis. Helicobacter pylori infection is related with the occurrence of gastritis, peptic ulcer and gastric malignancies, and these diseases and treatments are associated with osteoporosis. Meanwhile the application of proton pump inhibitor (PPI) can influence absorption of calcium, decrease the level of serum calcium and increase the risk of fracture. Gastrostomy may cause bone metabolism disorders.
