Factors related to the outcome of patients with chronic severe hepatitis B and effectiveness of antivirus therapy.
- Author:
Yun-zhong WU
1
;
Feng-lin ZHAO
;
Chun-ze ZHANG
;
Ming-hui LI
;
Yao XIE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Age Factors; Aged; Antiviral Agents; therapeutic use; Female; Hepatitis B e Antigens; blood; Hepatitis B virus; drug effects; genetics; Hepatitis B, Chronic; drug therapy; metabolism; mortality; Humans; Lamivudine; therapeutic use; Male; Middle Aged; Prothrombin; metabolism; Treatment Outcome; Viral Load
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(2):120-122
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the factors related to the outcome of patients with chronic severe hepatitis B and effectiveness of antivirus therapy.
METHODSThe effects of the factors including age, prothrombin activity (PTA), serum HBeAg, Anti-HBe, HBV-DNA load, with or without complication, antivirus therapy and so on, on outcome of 330 patients with chronic severe hepatitis B were analyzed in this retrospective study.
RESULTSThe mortality of patients with chronic severe hepatitis B was significantly higher among patients at higher age, with lower PTA, and with more complications. The mortality of patients with HBV-DNA more than 1x10(5) copies/ml (52.3 percent) was higher than that of patients whose HBV-DNA was less than 1x10(5) copies/ml (32.9 percent). There was no correlation between serum HBeAg or anti-HBe and the mortality. The mortality of patients with HBV-DNA higher than 1x10(5) copies/ml (30.38 percent) who were treated with lamivudine in 2005 was lower than that of patients whose HBV-DNA was less than 1x10(5) copies/ml (54.64 percent) who were not treated with any antiviral therapy in 2001.
CONCLUSIONThe higher serum virus load is the key factors of the mortality in addition to the other factors such as older age, lower PTA, more complication in the patients with chronic severe hepatitis B. The usage of antivirus therapy may be associated with lower mortality.
