Clinical characteristics of the patients with dengue fever seen from 2002 to 2006 in Guangzhou.
- Author:
Ruo-su YING
1
;
Xiao-ping TANG
;
Fu-chun ZHANG
;
Wei-ping CAI
;
Yan-qing CHEN
;
Jian WANG
;
Wen-xin HONG
;
Ying-zi LONG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Viral; blood; Child; Child, Preschool; China; epidemiology; Dengue; diagnosis; epidemiology; immunology; physiopathology; Dengue Virus; genetics; isolation & purification; Female; Humans; Infant; Male; Middle Aged; Retrospective Studies; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(2):123-125
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical characteristics of the patients with dengue fever (DF) seen from 2002 to 2006 in Guangzhou in order to prevent and treat dengue fever better.
METHODSClinical data from 1342 inpatients with DF seen from 2002 to 2006 were retrospectively analyzed. The dengue virus was isolated by C6/36 cell culture and genotyped by reverse transcriptase-polymerase chain reaction and gene sequence analysis.
RESULTSThe average age of the patients was 34.4 years, without sex difference in distribution. Most of the patients had obvious toxemic symptoms including fever (100 percent), headache (85.9 percent), myalgia (64.5 percent), bone soreness (46.6 percent) and skin rash (65.9 percent). Leukopenia, thrombocytopenia, elevated alanine aminotransferase, elevated aspartate aminotransferase and hypokalemia were found in 66.0 percent, 61.3 percent, 69.0 percent , 85.7 percent and 28.4 percent of patients, respectively. DF-IgM could be detected in 90 percent of patients. The virus was identified as dengue virus type-I.
CONCLUSIONSThe epidemic of DF was caused by dengue virus- I from 2002 to 2006 in Guangzhou. Most of the patients had classic DF clinical manifestation with high percentage of hepatic injury. Few patients progressed to dengue hemorrhagic fever.