Clinical significance of AFP-L3 variants determined by micro centrifugal column.
- Author:
Yong-zhong WANG
1
;
Li-bo LUO
;
Guo-xiang WU
;
Min CHEN
;
Li-hua RUAN
;
Xiang-ke PU
;
Shuang-rong HANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Carcinoma, Hepatocellular; blood; diagnosis; Centrifugation; Female; Humans; Liver Neoplasms; blood; diagnosis; Male; Middle Aged; alpha-Fetoproteins; analysis; isolation & purification
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(2):135-137
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the clinical significance of AFP-L3 in patients with hepatocellular carcinoma.
METHODSSerum AFP-L3 variants were separated by micro centrifugal column, and detected by chemiluminescence.
RESULTSAFP and AFP-L3 levels were higher in patients with hepatocellular carcinoma than those in patients with chronic hepatitis (P<0.001); as a diagnostic target, the sensitivity and specificity of AFP-L3 were 72.3 percent and 97.2 percent, respectively. Eight patients with hepatitis have higher AFP-L3, but none of them were found with carcinoma by CT three months later.
CONCLUSIONAFP-L3 is very useful in the diagnosis of patients with hepatocellular carcinoma.
