Study on the characteristic of Surveillance Creutzfeldt-Jakob disease patients from January to August in 2006 in China.
- Author:
Chen GAO
1
;
Jun HAN
;
Wei ZHOU
;
Jian-Ming CHEN
;
Qi SHI
;
Bao-Yun ZHANG
;
Ni-Juan XIANG
;
Yong-Jun GAO
;
Xiao-Ping DONG
Author Information
- Publication Type:Journal Article
- MeSH: 14-3-3 Proteins; cerebrospinal fluid; Adult; Aged; Blotting, Western; China; epidemiology; Creutzfeldt-Jakob Syndrome; cerebrospinal fluid; epidemiology; genetics; Female; Humans; Male; Middle Aged; Polymerase Chain Reaction; Population Surveillance; Prion Proteins; Prions; genetics
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(3):205-207
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo describe the incidence condition and characteristic of Creutzfeldt-Jakob disease (CJD) in China.
METHODSThe clinical and epidemical information of patients from China CJD surveillance network was analyzed. Blood and cerebrospinal fluid (CSF) specimens from these patients were differently collected to be used to detect the 14-3-3 protein in the CSF and to analyze the PRNP gene.
RESULTSTen possible and 8 probable clinically diagnosed CJD patients were found. These patients had sporadic CJD. There were no geographic clustering and occupational risk with these patients. The mean age at onset of disease was approximately 60 years. The male to female ratio was approximately 1:1; rapidly progressive dementia was the main early symptom, which was present in 44% of patients.
CONCLUSIONThe geographic distribution, occupation, the ratio of male to female and the mean age of onset were consistent with the characteristics of sporadic CJD.
