Expression of K18, Ser-33 and Ser-52 phosphorylated K18 in HBV infected human liver disease and its significance.
- Author:
Ying SHI
1
;
Juan LI
;
Lian-Chun LIANG
;
Ya-Song WU
;
Yu-Sen ZHOU
;
Xin-Yue CHEN
;
De-Xi CHEN
;
Hao WU
Author Information
- Publication Type:Journal Article
- MeSH: Hepatitis B; metabolism; Humans; Immunohistochemistry; Keratin-18; metabolism; Liver Cirrhosis; metabolism; pathology; virology; Liver Diseases; metabolism; pathology; virology; Phosphorylation; Serine; metabolism
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(3):220-222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of K18, Ser-33 and Ser-52 phosphorylated K18 in HBV infected human liver disease and its significance.
METHODSThe expression and localization of K18 and Ser-33, Ser-52 phosphorylated K18 in healthy liver tissue, in liver tissues of patients with post-HBV infection cirrhosis and severe chronic hepatitis were detected by histochemistry.
RESULTSK18, Ser-33 and Ser-52 phosphorylated K18 were expressed in normal liver cells, in liver tissues of cirrhosis patients and severe chronic hepatitis cases. The expression of K18 in the liver cells from the 3 different sources had no significant difference in levels. Ser-33 and Ser-52 phosphorylated K18 were expressed in normal liver cells, in liver tissues of cirrhosis patients chronicity HBV hepatitis and severe chronic hepatitis cases. Ser-33 and Ser-52 located around cytoplasmic membrane, diffused into cytoplasm and expressed at a higher levels in cirrhosis and severe chronic hepatitis.
CONCLUSIONThe expression levels of Ser-33 and Ser-52 phosphorylated K18 increased along with the progression of HBV infected human liver disease. The phosphorylation of K18 could be a marker of progression of HBV infected human liver disease.
