Concordance between hepatitis C virus serotype and genotype in chronic hepatitis C patients in China.
- Author:
Hui ZHAO
1
;
Ming-hui LI
;
Yao XIE
;
Shao-cai DU
;
Dao-zhen XU
Author Information
- Publication Type:Journal Article
- MeSH: Genotype; Hepacivirus; classification; Hepatitis C, Chronic; virology; Humans; Serotyping
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(4):355-357
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of hepatitis C virus (HCV) serotype with genotype.
METHODSThe serotypes of HCV in the serum of 104 patients with chronic hepatitis C from 14 cities in China for which HCV genotypes were available, were determined by ELISA using Murex HCV Serotyping 1-6 Assay.
RESULTSThe serotypes of 86 (82.69 percent) of the 104 serum specimens were determined, and HCV serotypes were determined for 91 strains. Overall the concordance between hepatitis C virus serotype and genotype was 62.1 percent, and the concordance of serotype, with genotypes 1, 2 and 3 were 69.4 percent, 51.2 percent and 70.0 percent, respectively. The false-negative rate and concordance of genotype 2b was lower (54.5 percent).
CONCLUSIONThe specificity of HCV serotyping was affected by HCV strains' genotype and sometimes HCV serotype was not in concordance with genotype.
