Effects of Kang Gang Qian Granule (KGQG) on clinical and pathological features in chronic hepatitis B patients.
- Author:
He-jie XIAO
1
;
Ci-guo SHI
;
Ai-ping ZHANG
;
Ping LI
;
Zhong-shan FAN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Collagen Type IV; analysis; Drugs, Chinese Herbal; therapeutic use; Female; Hepatitis B, Chronic; drug therapy; pathology; physiopathology; Humans; Immunohistochemistry; Liver Cirrhosis; drug therapy; pathology; Male; Medicine, Chinese Traditional; Middle Aged
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(4):369-371
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the efficacy of KGQG and its therapeutic mechanisms in chronic hepatitis B patients with liver fibrosis.
METHODS57 chronic hepatitis B patients with liver fibrosis were randomly divided into two groups: 45 cases in KGQG group were treated by KGQG and routine medications; 12 cases in control group were treated by routine medications only. Serum liver function test results, PCIII, CIV, HA and liver biopsy results of these 57 patients were simultaneously collected and analyzed before and after this intervention.
RESULTSKGQG group showed better efficacy over control group in liver function recovery, decrease of serum PCIII, CIV, HA levels and liver pathologic grades (P 0.05 or 0.01).
CONCLUSIONThe KGQG could effectively ameliorate liver function and facilitate the inhibition and degradation of liver fibrosis in chronic hepatitis B patients, which may be developed as a novel therapeusis to treat this hard-to-cure disease.
