Distribution of hepatitis B virus genotypes and its clinical significance.
- Author:
Hong-bin KONG
1
;
You-sheng LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; Female; Genotype; Hepatitis B virus; classification; genetics; Hepatitis B, Chronic; virology; Humans; Male; Middle Aged
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(4):372-373
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the distribution of hepatitis B virus genotypes in Handan area and clarify the genotype-related difference in clinic.
METHODSPolymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to detect the HBV genotypes in 108 HBV-infected patients from Handan area. The clinical significance of HBV genotype was analyzed in combination with the values of HBV DNA and ALT.
RESULTSAmong the 108 HBV-infected patients, the proportion of genotype B and C was 6.5 percent and 93.5 percent, respectively. Genotype distribution showed no significant difference between male and female patients. ALT and AST levels were higher in genotype C group than those in genotype B group.
CONCLUSIONHBV genotype C is predominant in chronic hepatitis B patients in Handan area. The positive rates of HBeAg and HBV DNA levels were higher in genotype C group than those in genotype B group. Genotype C was associated with the development of severe liver disease as compared to genotype B.