To explore the clinical significance of HBV large protein (HBV-LP) in diagnosing viral replication.
- Author:
Yu-hua GONG
1
;
Yun HU
;
Li-li ZHANG
;
Qin SU
;
Ren-lian DIAO
;
Jia-wen MIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; DNA, Viral; blood; Female; Hepatitis B Surface Antigens; blood; Hepatitis B e Antigens; blood; Hepatitis B virus; physiology; Humans; Male; Middle Aged; Virus Replication
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(4):380-382
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinical significance of HBV large protein (HBV-LP) in diagnosing viral replication, we detected the HBV-LP, HBV DNA and the hepatitis B viral markers (HBV M) in the serum of the patients infected with HBV.
METHODSHBV-LP and HBV M were analyzed by using ELISA. HBV-DNA was quantitatively detected using real-time fluorescent polymerase chain reaction.
RESULTS(1) No significant difference between the detectable rate of HBV DNA and HBV-LP was found in the same HBV M (P 0.05). (2) No significant difference between the positive rate of HBV DNA and HBV-LP was found in HBeAg negative patients. (3) The contents of serum HBV-LP was positively correlated with the number of HBV DNA copies.
CONCLUSIONThere was a close correlation between the positive rate of HBV-LP and HBV DNA, and HBV-LP is a reliable serological marker that can reflect the replication of HBV.
