Distribution of both HBsAg and HBsAb negative adults in Mianyang, Sichuan province.

Shuwen Cheng; Chuan Xiao; Min Wang; Lan Wang; Juan Wang; Tao Ren; Liping Wang; Xiaohua Wen; Wenhao Zhang; Ping Yuan

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Distribution of both HBsAg and HBsAb negative adults in Mianyang, Sichuan province.

Author: Shuwen CHENG ¹ ; Chuan XIAO ¹ ; Min WANG ¹ ; Lan WANG ² ; Juan WANG ³ ; Tao REN ⁴ ; Liping WANG ⁵ ; Xiaohua WEN ¹ ; Wenhao ZHANG ¹ ; Ping YUAN ¹
Author Information

1. West China School of Public Health, West China Hospital, Sichuan University, Chengdu 610041, China.
2. Respiratory and Critical Care Department, West China Hospital, Sichuan University, Chengdu 610041, China.
3. Infectious Disease Center, West China Hospital, Sichuan University, Chengdu 610041, China.
4. Fucheng District Center for Disease Control and Prevention, Mianyang City, Sichuan Province, Mianyang 621051, China.
5. Jiangyou County Center for Disease Control and Prevention, Sichuan Province, Jiangyou 621700, China.
Publication Type:Journal Article
MeSH: Adolescent; Adult; Aged; China; epidemiology; Enzyme-Linked Immunosorbent Assay; Ethnic Groups; Female; Health Personnel; Hepatitis B; epidemiology; Hepatitis B Antibodies; blood; Hepatitis B Surface Antigens; blood; Hepatitis B Vaccines; administration & dosage; Hepatitis B virus; Humans; Male; Middle Aged; Seroepidemiologic Studies; Surveys and Questionnaires; Vaccination; statistics & numerical data; Young Adult
From: Chinese Journal of Epidemiology 2016;37(1):60-63
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo understand the distribution of both HBsAg and HBsAb negative adults in Mianyang, Sichuan province, and provide evidences for the development of adult immunization policy.
METHODSFrom June 2013 to April 2014, a total of 200 929 people aged ≥15 years were selected in Mianyang through stratified cluster random sampling to conduct an interview with standard questionnaire. The blood samples were collected from them for the detection of HBsAg and HBsAb with enzyme-linked immunosorbent assay (ELISA).
RESULTSAmong the people surveyed, 13 903 were HBsAg positive (7.0%), 93 763 were HBsAb positive (46.6%), and 93 122 were both HBsAg and HBsAb negative (46.3%). The negative rate of both HBsAg and HBsAb in females (47.1%) was higher than that in males (45.4%). The negative rate of both HBsAg and HBsAb increased with age. The negative rate of both HBsAg and HBsAb was highest in people aged ≥65 years (50.3%) and lowest in people aged 15-24 years (42.9%). The negative rate of both HBsAg and HBsAb was highest in farmers (51.1%) and lowest in medical workers (24.1%). The negative rate of both HBsAg and HBsAb was highest in the widowed (51.1%) and lowest in the unmarried (41.6%). The negative rate of both HBsAg and HBsAb was lower in people with family history of hepatitis B (36.5%) than in people without family history of hepatitis B (46.6%). The negative rate of both HBsAg and HBsAb in Han ethnic group was lower (46.3%) than that in Qiang ethnic group (53.1%), but higher than that in other ethnic groups (43.9%). The negative rate of both HBsAg and HBsAb was higher in rural area (48.9%) than in urban area (43.0%). The negative rate of both HBsAg and HBsAb was lower in people who had received hepatitis B immunization (43.7%) than in people who had received no hepatitis B immunization (47.3%). The differences were all statistical significant (P<0.01).
CONCLUSIONThe negative rate of both HBsAg and HBsAb was 46.3% in people aged ≥15 years in Mianyang. General population are susceptible to hepatitis B virus infection. It is necessary to develop and implement appropriate hepatitis B immunization strategy for local adult population.