Characteristics of drug resistance and molecular type of Salmonella typhi and Salmonella paratyphi isolated in Henan province, 2009-2011
10.3760/cma.j.issn.0254-6450.2016.01.024
- VernacularTitle:河南省2009-2011年伤寒副伤寒沙门菌分子分型与耐药研究
- Author:
Jiayong ZHAO
1
;
Zhiqiang XIE
;
Yujiao MU
;
Jia SU
;
Shengli XIA
;
Xueyong HUANG
;
Bianli XU
Author Information
1. 河南省疾病预防控制中心
- Keywords:
Salmonella typhi/paratyphi;
Pulsed field gel electrophoresis;
Molecular typing;
Antibiotic susceptibility test
- From:
Chinese Journal of Epidemiology
2016;37(1):111-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antibiotic resistance and pulsed field gel electrophoresis (PFGE) patterns of clinical isolates of Salmonella (S.) typhi and S.paratyphi in Henan province during 2009-2011.Methods According to molecular typing and Salmonella K-B drug susceptibility test method published by international PulseNet bacterial infectious disease monitoring network and USA Clinical and Laboratory Standards Institute (CLSI),the drug susceptibility and PFGE molecule characteristics of 78 S.typhi and S.paratyphi strains isolated from sentinel hospitals in Henan were analyzed.Results The 78 strains orS.typhi and S.paratyphi were resistant to 13 kinds of antibiotics,in which 62 were multidrug resistant (79.5％),4 were resistant to 2-3 kinds of antibiotics (5.1％),41 were resistant to 5-8 kinds of antibiotics (52.6％),14 were resistant to 9-10 kinds of antibiotics (17.9％),3 were resistant to 11-12 kinds of antibiotics (3.8％).The resistant rate to cephalosporins,quinolones and other 3 kinds of antibiotic showed an increase trends.Seventy two strains ofS.typhi and S.paratyphi could be divided 14 molecular patterns by digestion with Xba Ⅰ and PFGE,each pattem contains 1-47 strains which shared the similarity of 66.03％-100.00％.Conclusions The drug resistance of clinical isolates of S.typhi and S.paratyphi was serious in Henan.The PFGE patterns showed diversity,but the predominant patterns could be still found.The PFGE patterns of some strains were associated with their drug resistance.
