Drop out of antiretroviral therapy in people living with AIDS/HIV and related factors in Nanjing and Yuncheng.

Meng LI; Hongxia Wei; Kai BU; Xiaoyan Liu; Yibing Feng; Lingen Shi; Xiayan Zhang; Yuheng Chen; Fangfang Chen; Xiaomin LI; Gengfeng FU; Xiping Huan; Lu Wang; Email: Wanglu64@163com

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Drop out of antiretroviral therapy in people living with AIDS/HIV and related factors in Nanjing and Yuncheng.

Author: Meng LI ¹ ; Hongxia WEI ² ; Kai BU ¹ ; Xiaoyan LIU ³ ; Yibing FENG ¹ ; Lingen SHI ³ ; Xiayan ZHANG ¹ ; Yuheng CHEN ³ ; Fangfang CHEN ¹ ; Xiaomin LI ⁴ ; Gengfeng FU ³ ; Xiping HUAN ³ ; Lu WANG ⁵ ; Email: WANGLU64@163.COM.
Author Information

1. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. The Second Hospital of Nanjing.
3. Jiangsu Provincial Center for Disease Control and Prevention.
4. Yuncheng Center for Disease Control and Prevention.
5. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Publication Type:Journal Article
MeSH: Acquired Immunodeficiency Syndrome; drug therapy; Anti-Retroviral Agents; administration & dosage; CD4 Lymphocyte Count; China; Communicable Diseases; Humans; Incidence; Medication Adherence; Proportional Hazards Models; Retrospective Studies
From:Chinese Journal of Epidemiology 2015;36(10):1113-1118
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo understand the incidence of drop out of antiretroviral therapy (ART) in people living with AIDS/HIV and related factors in Nanjing, Jiangsu province, and Yuncheng, Shanxi province.
METHODSRetrospective cohort analysis was conducted. The cumulative incidence curves of drop out of ART, mortality and drug withdrawal were drawn with Kaplan-Meier method. The related factors were identified with Cox proportional hazards regression model.
RESULTSA total of 1 006 patients were included in Yuncheng, the median length of ART follow-up was 49.59 months (QR: 20.02-92.84), and 976 patients were included in Nanjing, the median length of ART follow-up was 19.93 months (QR: 11.48-34.07). The cumulative incidence of drop out of ART at 3 months, 6 months, 1 year, 2 years, 4 years, 8 years after ART was 8.19%, 9.23%, 11.08%, 13.75%, 17.74%, 27.66% in Yuncheng, and 3.01%, 5.17%, 7.47%, 10.97%, 17.45%, 28.72% in Nanjing respectively. Age, marital status, infection route, baseline CD4 cell count, the clinical stage classified by WHO at the end of the observation were correlated with the drop out of ART.
CONCLUSIONIn order to reduce the drop out of ART among people living with AIDS/HIV, it is necessary to conduct effective interventions targeting the patients with young age, the patients who divorced/widowed, the patients who were intravenous drug users, the patients with higher CD4 cell count at the beginning of ART and clinical stage III or IV at the end of the follow-up and increase the coverage of HIV test.