Study on levels of serum phosphorus, bone alkaline phosphatase and 25-hydroxyvitamin D in preterm infants with very low birth weight
10.3760/cma.j.issn.0254-6450.2015.11.021
- VernacularTitle:极低出生体重早产儿血清磷、骨碱性磷酸酶、25-羟基维生素D水平动态变化分析
- Author:
Yue TIAN
1
;
Haixia WU
Author Information
1. 264001,山东省烟台市烟台山医院儿科
- Keywords:
Preterm infant with very low birth weight;
Serum phosphorus;
Bone alkaline phosphatase;
25-Hydroxyvitamin D3
- From:
Chinese Journal of Epidemiology
2015;36(11):1288-1290
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the levels of serum phosphorus,bone alkaline phosphatase and 25-hydroxyvitamin D3 in preterm infants with very low birth weight, and provide evidence for early screening, prevention of metabolic bone disease in preterm infants.Methods A total of 110 newborns who met the inclusion criteria were selected in pediatric ward in our hospital.The case group included 60 preterm infants with very low birth weight and control group included 50 full term infants.Fasting blood were taken from the subjects at week 1, 4, and 12 respectively, and ELISA was conducted to quantitatively detect the serum levels of phosphorus, bone alkaline phosphatase and 25-hydroxyvitamin D.Results The increase of serum 25-hydroxyvitamin D3 in case group was smaller than that in control group;the levels of serum phosphorus had no significant difference between two groups.In case group, the level of bone alkaline phosphatase increased at week 1,4, and 12, and the 25-hydroxyvitamin D3 level had significant difference at week 12 (P＜0.05).The abnormal rate of 25-hydroxyvitamin D3 level was 26.7％ for case group and 0％ for control group.Conclusion There were significant differences between case group and control group in levels of bone alkaline phosphatase and 25-hydroxyvitamin D3, suggesting that detecting the serum levels of bone alkaline phosphatase and 25-hydroxyvitamin D3 would facilitate the early diagnosis of metabolic bone disease in preterm infants.
