Synthesis and study on antibacterial and antifungal properties of 5-(5'-nitro-2'-furfuryliden)-thiazolidin-2,4-dion and derivatives
- Author:
Hai Thi Thanh Dinh
- Publication Type:Journal Article
- Keywords:
drug
- MeSH:
Pharmaceutical Preparations;
Antifungal Agents;
Anti-Bacterial Agents
- From:Pharmaceutical Journal
1998;265(5):12-14
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Nitration of furfural to give 5-nitrofurfural diacetat (NFD). By the condensation of NFD with thiazolidin-2,4-dione, derivative I was formed. Compound I underwent Mannich reaction and gave (II-IX) with formaldehyde (36% aqueous solution) and various amines. The structure of synthesized compounds were characterized by UV and IR. The obtained products were tested for biological activities such as antibacterial and antifungal. All synthesized compounds showed a high antibacterial activity on 9 strains of bacteria and antifungal activity against candida albicans. Among these, derivative VII showed the highest activity.
