Linkage analysis of susceptibility genes for familial schizophrenia on chromosome 1 in Chinese population.
- Author:
Guiqing CAI
1
;
Xinyao WU
;
Tao LI
;
David A COLLIER
;
Xiehe LIU
;
Bingjian FENG
;
Hong DENG
;
Dayue TONG
;
Jianjin LI
;
Jinghua OU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; China; Chromosome Mapping; Chromosomes, Human, Pair 1; genetics; Family Health; Female; Genetic Linkage; Genetic Predisposition to Disease; genetics; Humans; Lod Score; Male; Microsatellite Repeats; Middle Aged; Models, Genetic; Pedigree; Schizophrenia; genetics
- From: Chinese Journal of Medical Genetics 2002;19(6):491-494
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the molecular genetic relationship between chromosome 1 and susceptibility genes for familial schizophrenia in Chinese population.
METHODSA genome scanning was conducted in 32 multiplex pedigrees from Chinese population by using 29 microsatellite markers on chromosome 1.
RESULTSMultipoint parametric analysis detected a maximum heterogenicity Lod of 1.70 at 262.52 cM under a recessive model; multipoint non-parametric analysis detected a maximum non-parameter linkage (NPL) of 1.71 (P=0.046) at 262.52 cM, then 1.37 (P=0.086) at 149.70 cM, corresponding to marker D1S206 and D1S425 respectively.
CONCLUSIONThese results give further supports to the presence of susceptibility genes on chromosome 1q for familial schizophrenia.
