Association study of heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase gene.
- Author:
Liping CAO
1
;
Tao LI
;
Ke XU
;
Xiehe LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Alleles; Catechol O-Methyltransferase; genetics; DNA; genetics; metabolism; DNA Restriction Enzymes; metabolism; Female; Gene Frequency; Genotype; Heroin Dependence; enzymology; genetics; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; genetics
- From: Chinese Journal of Medical Genetics 2002;19(6):499-501
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the relationship between heroin-dependence and -287 A/G polymorphism of catechol-O-methyltransferase(COMT) gene.
METHODSGenotype and allele frequencies of -287 A/G polymorphism of COMT gene were examined in 268 heroin-dependent subjects and 177 normal controls.
RESULTSWeak but significant difference in genotype of -287 A/G polymorphism of COMT gene was observed between heroin-dependent subjects and controls (chi(2)=7.41, P=0.025), and genotype AA was higher in the former. The frequency of allele A of -287 A/G polymorphism of COMT gene was also significantly higher in heroin-dependent subjects than in the controls (chi(2)=5.69, P=0.017).
CONCLUSIONThe results suggested that liability to heroin-dependence was associated with -287 A/G polymorphism of COMT gene.
