Associations between six functional genes and schizophrenia.
- Author:
Ming-lian ZHANG
1
;
Guo-zhen YUAN
;
Jian-jun YAO
;
Yong-chao QIAN
;
Xia ZHANG
;
Yin-ping HUANG
;
Rui-chun TANG
;
Qing JI
;
San-duo JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Catechol O-Methyltransferase; genetics; DNA; genetics; Dopamine Plasma Membrane Transport Proteins; Female; Gene Frequency; Genetic Predisposition to Disease; genetics; Genotype; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; genetics; Middle Aged; Nerve Tissue Proteins; Polymorphism, Restriction Fragment Length; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; genetics; Receptors, Dopamine D4; Receptors, Serotonin; genetics; Schizophrenia; genetics
- From: Chinese Journal of Medical Genetics 2003;20(1):69-71
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the associations between schizophrenia and six functional genes: dopamine D2 receptor gene (DRD2), dopamine D4 receptor gene (DRD4), 5-hydroxytryptamine 2A receptor gene (5-HT2A), 5-HT6 receptor gene (5-HT6), catechol-O-methyltransferase gene (COMT) and dopamine transporter gene (DAT1).
METHODSWith the techniques of Amp-RFLP and Amp-FLP, association analysis was made between schizophrenia and the six genes in 67 schizophrenic patients from Chinese Han population.
RESULTS(1) Neither genotypes nor alleles of DRD2, 5-HT2A, 5-HT6 and COMT gene showed significant differences between patients and controls (P>0.05). (2) Six repeats (6R) in DRD4 gene, the allele of 480 bp and the genotype of 480/520 in DAT1 gene were found to be of significant differences between the two groups (P<0.05). (3) Only one negative association was observed between the 480 bp allele of DAT1 gene and schizophrenia (OR=0.441, 95% CI:0.202-0.963, Z=2.05, P<0.05).
CONCLUSIONThe 480 bp allele of DAT1 gene is negatively associated with schizophrenia in Chinese Han population, which stands for the dopamine hypothesis of schizophrenia.
