Association between HLA-DRB1, DQB1 genes and pemphigus vulgaris in Chinese Hans.
- Author:
Shu-hua ZHOU
1
;
Lin LIN
;
Pei-ying JIN
;
Shun-zhang YE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; China; DNA; genetics; Female; Gene Frequency; Genotype; HLA-DQ Antigens; genetics; HLA-DQ beta-Chains; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Male; Middle Aged; Pemphigus; genetics
- From: Chinese Journal of Medical Genetics 2003;20(1):79-81
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the predisposing role of HLA-DRB1, DQB1 genes in pemphigus vulgaris (PV).
METHODSPolymerase chain reaction-specific sequence primers method was used to type HLA-DRB1, DQB1 subregion in the patients with PV of Han nationality from Jiangsu and Anhui provinces and matched control subjects.
RESULTSDR4, DRB1*14(*1401,*1404,*1405) gene frequencies in PV patients were significantly higher than those in controls (Pc<0.05 and Pc<0.01 respectively). DQB1*0302, DQB1*0503 gene frequencies were significantly higher in PV patients (Pc<0.05). Further typing of DR4 positive subjects revealed that the gene frequencies of DRB1*0406, *0403 were significantly increased in PV patients as compared with controls (Pc<0.05). The haplotype frequencies of HLA-DRB1*04, DQB1*0302 and HLA-DRB1*14, DQB1*0503 in PV patients were significantly higher than those in controls (P<0.05).
CONCLUSIONThe results suggest that the combination of HLA-DRB1*4, DQB1*0302 and HLA-DRB1*14, DQB1*0503 forms putative susceptible haplotypes for PV patients in Chinese Hans.
