Mapping studies of type 2 diabetes mellitus gene in one family.
- Author:
Yuebin LI
1
;
Hong LU
;
Wei LIU
;
Chenhui ZHANG
;
Xiaoyan XIONG
;
Shijie XU
;
Wei HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Age of Onset; Aged; Aged, 80 and over; Chromosome Mapping; Chromosomes, Human, Pair 2; genetics; Diabetes Mellitus, Type 2; genetics; Family Health; Female; Genetic Linkage; Genetic Predisposition to Disease; genetics; Genome, Human; Humans; Lod Score; Male; Microsatellite Repeats; Middle Aged; Pedigree
- From: Chinese Journal of Medical Genetics 2003;20(2):123-126
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo disclose the molecular genetic mechanism of type 2 diabetes mellitus and to determine chromosomal location of type 2 diabetes mellitus gene.
METHODSGenome-wide screening and genotyping were conducted in a family of type 2 diabetes mellitus, and linkage analysis by LINKAGE and GENEHUNTER package was used to determine the potential chromosomal location of the family of type 2 diabetes mellitus gene.
RESULTSEvidence of linkage was found at the long arm of chromosome 2. The maximum Lod score is 1.80 and non-parameter Lod score is 5.06.
CONCLUSIONThe type 2 diabetes mellitus gene of the family is located at 2q.
