Association study of heroin dependence and catechol-O-methyltransferase gene.
- Author:
Liping CAO
1
;
Tao LI
;
Xiehe LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Catechol O-Methyltransferase; genetics; DNA; genetics; Female; Gene Frequency; Genotype; Heroin Dependence; enzymology; genetics; Humans; Male; Middle Aged; Mutagenesis, Insertional; Polymorphism, Genetic; Sequence Deletion
- From: Chinese Journal of Medical Genetics 2003;20(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the relationship between heroin dependence and catechol-O-methyltransferase (COMT) gene.
METHODSGenotype and allele frequencies of 108 val/met and 900 Ins C/Del C polymorphisms of COMT gene were examined in 313 heroin-dependent subjects and 214 normal controls.
RESULTSNo differences in genotype and allele frequencies of 108 val/met polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=1.67, P=0.43; allele-wise: chi-square=1.23, P=0.27). No differences in genotype and allele frequencies of 900 Ins C/Del C polymorphism of COMT gene were observed between heroin-dependent subjects and normal controls (genotype-wise: chi-square=3.73, P=0.16; allele-wise: chi-square=0.76, P=0.38).
CONCLUSIONThe results suggested that neither 108 val/met polymorphism nor 900 Ins C/Del C polymorphism of COMT gene was associated with heroin dependence.
