Study on the association of lecithin cholesterol acyltransferase gene polymorphisms with the lipid metabolism in coronary atherosclerotic heart disease.
- Author:
Kelan ZHANG
1
;
Sizhong ZHANG
;
Keqin ZHENG
;
Yong HE
;
Li ZHANG
;
Zhiguang SU
;
Yan SUN
;
Jiajun SHI
;
Xiangdong KONG
;
Yu TONG
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; China; Cholesterol; blood; Cholesterol, HDL; blood; Cholesterol, LDL; blood; Cholesterol, VLDL; blood; Coronary Artery Disease; enzymology; genetics; DNA; genetics; metabolism; DNA Restriction Enzymes; metabolism; Female; Gene Frequency; Genotype; Humans; Lipid Metabolism; Lipids; blood; Male; Middle Aged; Phosphatidylcholine-Sterol O-Acyltransferase; genetics; metabolism; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Triglycerides; blood
- From: Chinese Journal of Medical Genetics 2003;20(2):135-137
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the distribution of 3 polymorphisms of lecithin cholesterol acyltransferase gene in Chinese population and the association of these polymorphisms with lipid metabolism in patients with atherosclerotic heart disease (CHD).
METHODSGenotypes and frequencies of 3 sites were examined by PCR-restriction fragment length polymorphism technique in 209 unrelated normal control individuals and 203 CHD patients.
RESULTSThe observed allele frequencies conform well to Hardy-Weinberg equilibrium. The frequency of 608T allele was significantly higher in controls than that in patients (P=0.034). Compared with the CHD patients without 608T, the CHD patients with 608T exhibited a significant increase in plasma HDL-C concentration (P=0.015). 911T/C and 1188C/T polymorphisms were not found in either group.
CONCLUSION608T polymorphism of LCAT gene was associated with higher plasma HDL-C level in CHD patients, while 911T/C and 1188C/T polymorphisms maybe very rare in Chinese population.
