Advances in modulation of mammalian sperm function by fertilization promoting peptide.
- Author:
Yongxin MA
1
;
Sizhong ZHANG
Author Information
1. Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041 P. R. China. szzhang@mcwcums.com
- Publication Type:Journal Article
- MeSH:
Acrosome;
drug effects;
Adenylyl Cyclases;
metabolism;
Animals;
Cyclic AMP;
metabolism;
Humans;
Male;
Pyrrolidonecarboxylic Acid;
analogs & derivatives;
Signal Transduction;
drug effects;
Spermatozoa;
drug effects;
physiology;
Thyrotropin-Releasing Hormone;
analogs & derivatives;
pharmacology
- From:
Chinese Journal of Medical Genetics
2003;20(2):151-155
- CountryChina
- Language:Chinese
-
Abstract:
Both fertilization promoting peptide and adenosine stimulate capacitation but inhibit spontaneous acrosome loss by modulation of the adenylyl cyclase (AC)/cAMP signal transduction pathway. This is a review aimed at analyzing the function of fertilization promoting peptide during this process. The possible molecular basis is also discussed.
