Prevalence and Related Factors of Vitamin D Deficiency in Critically Ill Patients.
10.4266/kjccm.2016.00276
- Author:
Hyun Jung KIM
;
Min Su SOHN
;
Eun Young CHOI
- Publication Type:Original Article
- Keywords:
25-hydroxyvitamin D;
calcitriol;
critical care;
intensive care units;
vitamin D deficiency
- MeSH:
APACHE;
Body Mass Index;
Calcitriol;
Chronic Disease;
Critical Care;
Critical Illness*;
Humans;
Intensive Care Units;
Mortality;
Prevalence*;
Respiration, Artificial;
Retrospective Studies;
Tertiary Healthcare;
Vitamin D Deficiency*;
Vitamin D*;
Vitamins*
- From:Korean Journal of Critical Care Medicine
2016;31(4):300-307
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: To identify the prevalence and related factors for vitamin D deficiency in the patients who admitted to the medical intensive care unit (ICU) of a Korean tertiary care hospital. METHODS: We retrospectively analyzed the data from ICU patients requiring mechanical ventilation (MV) for a period of > 48 h to identify the prevalence and associated factors for vitamin D deficiency. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D [25(OH)D] level < 20 ng/mL. RESULTS: Among 570 patients admitted to the ICU, 221 were enrolled in the study, 194 in the vitamin D deficient group and 27 in the non-deficient group. Prevalence of vitamin D deficiency in critically ill patients was 87.8%. The patient age was lower in the vitamin D deficient group compared with the non-deficient group (64.4 ± 15.4 vs. 71.0 ± 9.6 years, p = 0.049). A higher acute physiology and chronic health evaluation II (APACHE II) score (odds ratio [OR] 1.23, 95% confidence interval [CI] 1.10-1.37) and chronic illness (OR 3.12, 95% CI 1.08-9.01) were associated with vitamin D deficiency after adjusting for age and body mass index. Clinical outcomes of duration of MV, ICU stay, and 28- and 90-day mortality rates were not significantly different between the vitamin D deficient and nondeficient groups. CONCLUSIONS: Vitamin D deficiency was common in critically ill patients, particularly among younger patients. Higher APACHE II score and chronic illness were associated with vitamin D deficiency.
