Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women.
- Author:
Jun CHEN
1
;
Liping ZHANG
;
Junfeng QIU
;
Hui PENG
;
Zhongliang DENG
;
Yujun WANG
;
Zhongde YAN
Author Information
- Publication Type:Journal Article
- MeSH: DNA; genetics; metabolism; Deoxyribonucleases, Type II Site-Specific; metabolism; Female; Gene Frequency; Genotype; Humans; Middle Aged; Osteoporosis, Postmenopausal; genetics; Polymorphism, Genetic; Receptors, Calcitriol; genetics
- From: Chinese Journal of Medical Genetics 2003;20(2):167-168
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women.
METHODSThe polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women.
RESULTSIn the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85.71%, 14.29% and 0, respectively (P>0.05).
CONCLUSIONSignificant association between VDR genotype and osteoporosis in Chinese women was observed in this study.
