Clinical and experimental studies on five cases of acute myeloid leukemia with translocation t(16;21)(p11;q22).
- Author:
Yafang WU
1
;
Yongquan XUE
;
Jinlan PAN
;
Qinfeng MA
Author Information
- Publication Type:Case Reports
- MeSH: Acute Disease; Adolescent; Adult; Cells, Cultured; Child; Chromosomes, Human, Pair 16; genetics; Chromosomes, Human, Pair 21; genetics; Female; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Leukemia, Myeloid; genetics; Male; Translocation, Genetic
- From: Chinese Journal of Medical Genetics 2003;20(2):171-173
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo report five cases of acute myeloid leukemia (AML) with t(16;21)(p11;q22) translocation and the result of chromosome painting analysis on one of them.
METHODSChromosome specimens were prepared by short-term culture of bone marrow cells. Karyotype analysis was made by R-banding technique. Chromosome painting was performed using whole chromosome probes 16 and 21 in 1 case.
RESULTSKaryotype analysis showed identical translocation t(16;21)(p11;q22) in all five cases, accounting for 0.3% of 1448 cases of acute myeoid leukemia examined in the past fifteen years. Moreover, chromosome painting distinctly demonstrated t(16;21) in one of them. Leukemia blasts did not show hemophagocytosis in all of them.
CONCLUSIONt(16;21) translocation is a rare and recurring chromosome rearrangement. It represents a specific type of AML. Chromosome painting technique is a more reliable means for detecting it, compared with the conventional karyotype analysis.
