Study on a new point mutation of nt3426 A --> G of mitochondrial DNA in a diabetes mellitus family.
- Author:
Pei YU
1
;
De-min YU
;
De-min LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; DNA, Mitochondrial; analysis; genetics; Diabetes Mellitus, Type 2; genetics; Family; Humans; Male; Middle Aged; Pedigree; Point Mutation; Polymerase Chain Reaction; Young Adult
- From: Chinese Journal of Medical Genetics 2003;20(3):235-237
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo elucidate the relationship between point mutations of nt3243A --> G, nt3426 A --> G of mitochondrial DNA and type 2 diabetes mellitus(DM).
METHODSTwo hundred patients with type 2 DM and 180 controls with normal glucose tolerance and absence of DM family history were included. The mutations were determined by PCR-restriction fragment length polymorphism.
RESULTSThe point mutation nt3426A --> G of mitochondrial DNA ND1 was found in 2 of the patients with type 2 DM (1.0%) but in none of the controls (0). The incidence of this mutation showed no significant difference between the two groups(P>0.05). And none was found to have the mutation of nt3243 --> G.
CONCLUSIONThe point mutation nt3426 A --> G of mitochondrial DNA ND1 may not be an independent factor to cause type 2 DM.
