Dopamine beta hydroxylase gene polymorphism and Parkinson's disease.
- Author:
Xiao-ping ZHAO
1
;
Hui-jun XIE
;
Guo-mei TANG
;
Wu-wei ZHAO
;
Ling XU
;
Jing-jing SU
;
Yi-xin HAO
;
Da-ming REN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; genetics; China; Dopamine beta-Hydroxylase; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Parkinson Disease; genetics; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Medical Genetics 2003;20(3):238-240
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between the polymorphism of dopamine beta hydroxylase(DBH) gene and the susceptibility of Shanghai Chinese Han population to Parkinson's disease(PD).
METHODSAssociation study was performed in 144 PD patients and 188 healthy control subjects matched for age, sex and origin. Polymorphism of DBH gene was analyzed with polymerase chain reaction-restriction fragment length polymorphism.
RESULTSThe allelic frequency of A2 allele of DBH gene was significantly higher in PD patients than in controls(P<0.01).The risk of suffering from PD increased (OR=1.82) in the individual with A2 allele. And the genotypic frequency of A2/A2 was significantly higher in PD patients(OR=2.11, P<0.01),too. On the other hand, the allelic frequency of A1 allele and the genotypic frequency of A1/A2 genotype of DBH gene in PD patients were significantly lower(A1 alleles: OR=0.54, P<0.01; A1/A2 genotypes: OR=0.45, P<0.01).
CONCLUSIONThe polymorphism in DBH gene might play an important role in the susceptibility of Shanghai Chinese Han population to PD.
