Relationship between apolipoprotein E and apolipoprotein B polymorphisms in youths with coronary heart disease.
- Author:
Sha LI
1
;
Zhao-wen LEI
;
Zili CHEN
;
Da LIN
;
Xi-song KE
;
Yao-ming ZHONG
;
Su-fen WU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Alleles; Apolipoproteins B; genetics; Apolipoproteins E; genetics; Coronary Disease; genetics; Female; Gene Frequency; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Young Adult
- From: Chinese Journal of Medical Genetics 2003;20(3):241-243
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate hereditary susceptibility to coronary heart disease (CHD) in apolipoprotein E(apo E) and apo B polymorphisms of youths.
METHODSPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze apoE, apoB Xba I, apoB 3' variable number of tandem repeat (VNTR) genotypes for 244 healthy Han students (among them were 109 students with positive CHD family history).
RESULTSThe allele frequencies of apo e4, XbaI x(+), 3'VNTR-B(hypervariable element, HVE>38) in the positive group were obviously higher than those in the negative group(P<0.05), and were significantly correlated with the increase in TC, LDL-C, apoB100 levels (P<0.05).
CONCLUSIONThe alleles for apo e4, XbaI x(+), 3'VNTR-B may be the important genetic markers of Han CHD.
