The association of HLA-DRB1 allele polymorphism with the genetic susceptibility to liver cirrhosis due to hepatitis B virus.
- Author:
Yuan-qiao CHENG
1
;
Ju-sheng LIN
;
Li-hong HUANG
;
De-ying TIAN
;
Ping XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Genetic Predisposition to Disease; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Hepatitis B; complications; genetics; Hepatitis B virus; genetics; pathogenicity; Hepatitis B, Chronic; complications; genetics; Humans; Liver Cirrhosis; etiology; genetics; Male; Middle Aged; Polymorphism, Genetic
- From: Chinese Journal of Medical Genetics 2003;20(3):247-249
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of human leucocyte antigen (HLA)-DRB1 allele with the genetic susceptibility to cirrhosis due to hepatitis B virus(HBV).
METHODSOne hundred and six patients with cirrhosis due to HBV in Hubei area were investigated for HLA-DRB1 gene by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 108 normal healthy people.
RESULTSThe frequency of HLA-DRB1*1201/1202 allele was 20.28% in patient group, which was significantly higher than the frequency (6.01%) in control group, the relative risk (RR) being 4.9878 (P<0.01). The frequency of HLA-DRB1*1501/1502 allele was decreased in patient group (patient 6.6%, control 16.67%, RR=0.3043, P<0.05), while the frequencies of other HLA-DRB1 alleles were not significantly different(P>0.05).
CONCLUSIONHLA-DRB1*1201/1202 allele may be the susceptibility gene in patients with cirrhosis due to HBV in Hubei Han nationality; HLA-DRB1*1501/1502 allele is a resistant gene in patients with cirrhosis.
