Association study on HLA-DP and -DQ allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province.
- Author:
Jin-feng ZHOU
1
;
Shi-shi GUO
;
Ping YU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; genetics; China; ethnology; Female; Genetics, Population; HLA-DP Antigens; genetics; HLA-DQ Antigens; genetics; HLA-DQ alpha-Chains; HLA-DQ beta-Chains; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; genetics
- From: Chinese Journal of Medical Genetics 2003;20(3):262-264
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate whether the polymorphisms of HLA-DPA1,DPB1,DQA1 and DQB1 alleles were associated with nasopharyngeal carcinoma(NPC).
METHODSEighty-seven NPC patients and 91 normal controls of Han nationality in Hunan province were genotyped for HLA-DPA1, HLA-DPB1,HLA-DQA1 and HLA-DQB1 by PCR/SSO technique.
RESULTSThe frequencies of allelic gene DPA1*0201, DPB1*1901 and DQA1*0201 were lower, and of DPB1*0402, DQA1*0101 were higher in patients than in controls; the frequencies of haplotype DPA1*0201-DPB1*1401 and DQA1*0201-DQB1*0201 in patients were lower than those in controls; however, the values of P are not significant after Bonferroni correction(Pc>0.05).
CONCLUSIONNo significant association between the HLA-DP and HLA-DQ loci and NPC in Han nationality in Hunan province was confirmed.
