Association between gene mutation of cytochrome P450 1A1 in exon 7 A4889G locus and susceptibility to endometriosis.
- Author:
Dong-xian PENG
1
;
Yuan-li HE
;
Li-wen QIU
;
Fang YANG
;
Jing-ming LIN
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Cytochrome P-450 CYP1A1; genetics; Endometriosis; genetics; Exons; genetics; Female; Genetic Predisposition to Disease; genetics; Genotype; Humans; Mutation; Polymerase Chain Reaction; Pregnancy
- From: Chinese Journal of Medical Genetics 2003;20(4):284-286
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the possible association between gene mutation of cytochrome P450 1A1(CYP1A1) in exon 7 A4889G locus and the susceptibility to endometriosis (EM).
METHODSAllele specific-polymerase chain reaction method was used to analyze gene mutation in exon 7 A4889G locus of CYP1A1 in 76 patients with endometriosis and 80 healthy controls.
RESULTSThe frequency of allele G on A4889G locus of CYP1A1 gene showed a significant difference between the study cohort and the control group (Chi2=7.498, P<0.01), with an odds ratio of 1.957. Statistically significant difference in the frequencies of genotypes AA, AG and GG was observed between the two groups (Chi2=6.915, P<0.05). Individuals with homozygotes for G allele were at higher risk of suffering from EM when compared against those with homozygotes for A allele, the odds ratio being 3.437 (Chi2=5.430, P<0.05).
CONCLUSIONThe above results suggest that gene mutation of CYP1A1 in exon 7 A4889G locus might be a genetic susceptible factor of endometriosis. The mutation allele of CYP1A1 gene appears to increase the risk of endometriosis.
