Impact of overweight on postoperative complications and oncological outcome after radical hepatectomy for metastatic colorectal cancer.

Hongwei Wang; Kun Wang; Quan Bao; Yi Sun; Kemin Jin; Xiaoluan Yan; Baocai Xing; Email: Xingbaocai88@sinacom

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Impact of overweight on postoperative complications and oncological outcome after radical hepatectomy for metastatic colorectal cancer.

Author: Hongwei WANG ¹ ; Kun WANG ¹ ; Quan BAO ¹ ; Yi SUN ¹ ; Kemin JIN ¹ ; Xiaoluan YAN ¹ ; Baocai XING ² ; Email: XINGBAOCAI88@SINA.COM.
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1. Key Laboratory of Carcinogenesis and Translational Reaserch (Ministry of Education), the First Department of Hepatopancreatobiliary Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China.
2. Key Laboratory of Carcinogenesis and Translational Reaserch (Ministry of Education), the First Department of Hepatopancreatobiliary Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China
Publication Type:Journal Article
MeSH: Colorectal Neoplasms; epidemiology; surgery; Disease-Free Survival; Hepatectomy; statistics & numerical data; Humans; Liver Neoplasms; epidemiology; secondary; surgery; Overweight; Postoperative Complications; epidemiology; Prognosis; Retrospective Studies; Survival Rate
From: Chinese Journal of Oncology 2015;37(3):200-203
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo evaluate the correlation between overweight and postoperative complications and prognosis after radical hepatectomy for colorectal liver metastasis (CRLM).
METHODSA total of 192 patients who underwent hepatectomy for colorectal liver metastases between January 2000 and March 2012 were eligible for the study. We retrospectively summarized their clinicopathological data, BMI index and postoperative complications, and investigated the relation between these data and complications and prognosis.
RESULTSOf the 192 patients, 109 cases were classified as overweight with a BMI ≥24 and 83 patients were classified as non-overweight with a BMI <24. Seventy-five complications occurred in 68 of the 192 patients (35.4%) who underwent hepatectomy. Surgical complications (P=0.428), operation time (P=0.837), and blood loss (P=0.272) were not statistically significantly associated with BMI. 173 patients were included to analyze the influence of overweight on oncologic outcome. The median survival for the overweight patients was 59 months, while that of non-overweight patients was 31 months (P=0.016). The overweight patients had a longer OS assessed by both univariate analysis (P=0.016) and multivariate analysis (P=0.031). However, no statistical differences in disease-free survival (DFS) were detected between the overweight and non-overweight groups (P=0.058).
CONCLUSIONSOverweight is not independently associated with an increasing complication rate. BMI does not significantly affect the CRLM-DFS, and high BMI patients might have a better overall survival.