Comparison of the effectiveness of percutaneous microwave ablation versus hepatectomy for hepatocellular carcinoma.
- Author:
Li SHENG
;
Yiqi WANG
;
Dong JUN
;
Wu PEIHONG
- Publication Type:Journal Article
- MeSH: Carcinoma, Hepatocellular; mortality; radiotherapy; surgery; Catheter Ablation; Genetic Engineering; Hepatectomy; mortality; Humans; Liver Neoplasms; mortality; radiotherapy; surgery; Microwaves; therapeutic use; Regression Analysis; Survival Rate; Treatment Outcome
- From: Chinese Journal of Oncology 2015;37(4):301-307
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the effectiveness of percutaneous microwave ablation ( MWA) versus hepatectomy for multifocal hepatocellular carcinoma.
METHODSFrom August 2002 to March 2012, one hundred and twenty-two patients with multifocal hepatocellular carcinoma (diameters 1 to 7 cm, 2 to 4 lesions) were treated by either complete MWA or radical hepatectomy, and their clinical data were collected and analyzed.The patients were divided into MWA group (n = 50) and resection group (n = 72), and the resection group was matched by MWA group based on clinical parameters. The survival and complications in the two groups were compared.
RESULTSThe overall 1-, 3- and 5-year survival rates were 100.0%, 73.0% and 62.0%, respectively, in the MWA group, and 80.0%, 56.0%, and 41.0%, respectively, in the resection group (P < 0.05). The corresponding recurrence-free survival rates were 88.0%, 63.0%, and 52.0% in the MWA group, and 68.0%, 45.0%, and 36.0%, respectively, in the resection group (P< 0.05). The multivariate Cox regression analysis indicated that albumin level, performance status, treatment modality, and tumor size were independent prognostic factors.
CONCLUSIONCompared with hepatectomy, percutaneous microwave ablation is a minimally invasive and reproducible procedure, and can improve the survival in patients with multifocal hepatocellular carcinoma.