Research on the relationship between obstructive sleep apnea hypopnea syndrome and nocturnal laryngopharyngeal reflux
10.3321/j.issn:1673-0860.2008.03.002
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征与夜间咽喉反流的相关性研究
- Author:
Xiao-Ye WANG
1
;
De-Min HAN
;
Jing-Ying YE
Author Information
1. 苏州大学附属第三医院
- Keywords:
Sleep apnea,obstructive;
Gastroesophageal reflux;
Hydrogen-Ion concentration;
Pharyngeal diseases;
Pressoreceptors
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(3):163-168
- CountryChina
- Language:Chinese
-
Abstract:
Objectlve To study the relationship between obstructive sleep apnea hypopnea syndrome(OSAHS) and nocturnal laryngopharyngeal reflux(LPR),and discuss the possible mechanism.Methods Nineteen OSAHS patients had PSG,nocturnal pH and introesophageal pressure monitoring simultaneously. The sleep stage,body position and pressure change were recorded during every reflux event.The relationship between obstructive sleep apnea(OSA)and LPR was analyzed. Results Among 19 OSAHS patients,6 cases were found to have LPR,and 63 reflux events were recorded. There was a negative relationship between the severity of OSAHS and nocturnal mean laryngopharyngeal pH value,but relationship between OSA and reflux events is not statistically significant. The introesophageal pressure(t=3.211,P=0.007) and upper esophageal sphincter(UES) pressure(t=2.234,P=0.046) were statistically different between the patients with and without LPR. There was a positive relationship between the mean value of introesophageal pressure and the whale night mean laryngopharyngeal pH value(r=0.592,P=0.033).Conclusions There was significant relationship between severity of OSAHS and nocturnal laryngopharyngeal pH value. OSAHS patients are more likely to have esophageal reflux which could increase LPR,Compared with OSAHS patients without LPR,UES pressure during the night decreased significandy in those cases with LPR,it suggested this could be another mechanism of LPR.
