Growth retardation in children with obstructive sleep apnea hypopnea syndrome
10.3321/j.issn:1673-0860.2008.03.004
- VernacularTitle:儿童阻塞性睡眠呼吸暂停低通气综合征与生长发育迟缓的关系
- Author:
Jin HOU
1
;
Quan-Qing KANG
;
Guo-Xi ZHENG
Author Information
1. 西安交通大学医学院附属第二医院
- Keywords:
Child;
Sleep apnea,obstructive;
Boay height;
Insulin-like growth factor Ⅰ;
Polysomography
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(3):174-178
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes of growth,body composition and biochemical markers associated with growth(IGF-1) in prepubertal children with obstructive sleep apnea syndrome(OSAHS).Methods Thirty-one children aged 3-10 years with OSAHS were followed up for 1 year after the corresponding surgery. During the same period of time,20 children of similar age without OSAHS(excluded any other diseases that could result growth retardation or hypoxemia) were also followed up for 1 year. PSG,height,weight as well as insulin-like growth factor-1 (IGF-1) were measured during the preoperative period,3 months,6 months and 1 year after surgery in patient group. The same indexes were measured before surgery,and only height and weight were recorded after surgery in the control group. Wilcoxon signed-rank test and Mann- Whitney U test are used to analyze the data. Results The lowest oxyhemoglobin saturation of the patient group(0.88) is significantly lower than that of the control group(0.98),and was found increased at the 6 months post-op follow up(0.97,U=238.5,P＞0.05),no significant change was found at the 1 year follow up. The post-op AHI(6 months after surgery) of the patient group(6.0/h) decreased to the similar level of the control group(0/h,U=240.0,P＞0.05),and was similar to 1 year after surgery. Height of the patient group(116 cm),which was lower than the control group(U=127.0,P＜0.001),significantly increased 1 year(138 cm) after the corresponding surgery(Z=3.726,P＜0.01),and reached the similar levels of the control group(137 cm) 1 year after the surgery(U=123.5,P＞0.05).The serum IGF-1 levels of the patient group(33.7 ng/ml),which were significantly lower than those of the controls preoperatively(44.1 ng/ml,U=206.0,P＜0.05),increased to similar levels with the controls 6 months after the operation(50.3 ng/ml,U=261.0,P＞0.05),and the 1 year post-op follow up was similar to the control group too(48.6 ng/ml,U=163.0,P＞0.05). Conclusions The care of OSAHS could accelerate growth in prepubertal children,and the serum IGF-1 levels increases at the same time. The growth retardation is presumed in children with OSAHS.
