Concurrent chemoradiotherapy versus radiotherapy alone for locoregionally advanced nasopharyngeal carcinoma:a Meta-analysis
10.3321/j.issn:1673-0860.2008.03.013
- VernacularTitle:同步放化疗与单纯放疗在晚期鼻咽癌中疗效比较的Meta分析
- Author:
An-Kui YANG
1
;
Tian-Run LIU
;
Xiang GUO
;
Guo-Long QI
;
Fu-Jin CHEN
;
Zhu-Ming GUO
;
Quan ZHANG
;
Zong-Yuan ZENG
;
Wei-Chao CHEN
;
Qiu-Li LI
Author Information
1. 中山医科大学附属肿瘤防治中心
- Keywords:
Nasopharyngeal neoplasms;
Drug therapy,combination;
Radiotherapy;
Metaanalysis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(3):218-223
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the value of concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma from the mainland of China. Methods Data were extracted from randomized trials comparing chemotherapy plus radiotherapy with radiotherapy alone in locally advanced nasopharyngeal carcinoma. Actuarial rates of survival and distant metastases were calculated. The followed electronic databases were searched the Chinese Biomedicine database,Pubmed,Medline,Embase and Cochrane library:Data were extracted by tow reviewers and Review manager 4.1 software was applied for statistical analysis. Results Eighteen trials with 1993 patients were include according to the including criterion. The 3-year overall survival rate of the chemoradiotherapy group and the radiotherapy group were 68.47% and 56.38% respectively, and the 5-year overall survival rate of the two groups above were 51.91% and 41.09% respectively, while the distant metastases rate of the chemoradiotherapy group and the radiotherapy group were 26.19% and 38.71% respectively. The result demonstrated that chemoradiotherapy increased overall survival by 12% at 3 years, and 11% at 5 years after treatment. After chemoradiotherapy,the rate of distant metastasis was reduce by 12%. Conclusions In patients with locoregionally advanced nasopharyngeal carcinoma,chemoradiotherapy significantly improves overall survival at 3 years,and 5 years compared with radiotherapy alone.
