Association between genetic polymorphisms in methylenetetrahydrofolate reductase and risk of laryngeal squamous cell carcinoma
10.3321/j.issn:1673-0860.2008.06.009
- VernacularTitle:亚甲基四氢叶酸还原酶基因多态与喉鳞状细胞癌风险关联
- Author:
Xin NI
1
;
Jun TAI
;
Li-Jing MA
;
Zhi-Gang HUANG
;
Ju-Gao FANG
;
Xiao-Hong CHEN
;
Wei ZHANG
;
Li-Ping ZHAO
;
Xin-Xin LU
;
De-Min HAN
Author Information
1. 首都医科大学附属北京同仁医院
- Keywords:
Laryngeal neoplasms;
Genetic polymorphism;
Disease susceptibility
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2008;43(6):435-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether genetic variations in methylenetetrahydrofolate reductase (MTHFR) are associated with the risk of laryngeal squamous cell carcinoma(LSCC)in a Chinese population.Methods Two hundred and seven cases with LSCC and 400 matched health controls were genotyped for the MTHFR 677C>T and 1298A>C polymorphisms by PCR-restriction fragment length polymorphism(PCR-RFLP)methods.The relation between these genotypes and risk of LSCC and gene-environment interaction were analyed.The adjusted odds ratios (OR) and 95%confidence intervals (CI) were calculated by using unconditional Logistic regression model.Results The individuals with 677CT and 677TT genotype had a 1.66-fold(95%C/1.08～2.52)and 3.35-fold (95%C/2.07-5.54)increased risk of developing LSCC comared with those who had 677CC genotype.The individuals with MTHFR 1298A>C genotype was not significantly different between the two groups.Furthermore,cigarette smoking Was also found to interact with MTHFR 677C>T polymorphism in increasing the risk to LCSS further demonstrating the role of gene-environment interaction in development of LSCC.Conclusions These findings suggested that the MTHFR 677C>T polymorphism may contribute to the risk of developing LSCC among Chinese population.
