Role of IGF2 Gene in Developing Human Ovary.
10.11637/kjpa.1996.9.2.141
- Author:
Hyung Tae PARK
;
Hong Tae KIM
;
Bo Hwa CHOI
;
Jung Ran KIM
;
Daeg Kwang KIM
;
In Jang CHOI
;
In Hwan LEE
;
Sung Ik CHANG
- Publication Type:Original Article
- Keywords:
Monoclonal antibody;
IGF2 gene;
Theca cell;
Progesterone
- MeSH:
Carcinogenesis;
Corpus Luteum;
Epithelial Cells;
Epithelium;
Female;
Humans*;
Ovary*;
Ovulation;
Ovum;
Progesterone;
Theca Cells
- From:Korean Journal of Physical Anthropology
1996;9(2):141-147
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To understand the role of IGF2 gene in development of human ovary, IGF2 expression was detected by monoclonal antibody for IGF2 to its producted protein with immunohistochemical technique on human ovarian tissues. The results was as follows. IGF2 was highly expressed in ovum of mature follicle, IGF2 expression, however, was not high in granulosa and the cells. IGF2 was not highly expressed in ovum of primary follicle. Highly expressed IGF2 was found on corpus luteum and no expression of IGF2 was found in stroma and epithelial cells. These results suggest that IGF2 is important role in ovulation and in production of progesterone. Abnormal IGF2 expression may be concerned to carcinogenesis of ovarian tumor because most of all tumor from ovary is originated from epithelium.
