Role of BK(Ca) channels in diabetic vascular complications.
- Author:
Lingling QIAN
1
;
Xiaoyu LIU
1
;
Ruxing WANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Cerebral Arterial Diseases; metabolism; Coronary Artery Disease; Diabetic Angiopathies; metabolism; Diabetic Retinopathy; metabolism; Humans; Large-Conductance Calcium-Activated Potassium Channels; metabolism
- From: Chinese Medical Journal 2014;127(9):1775-1781
- CountryChina
- Language:English
-
Abstract:
OBJECTIVEThis review focuses on the role of the large conductance calcium-activated potassium (BKCa) channels in diabetic vascular complications.
DATA SOURCESRelevant articles published in English or Chinese from 1981 to present were selected from PubMed. The search terms were "BKCa channels" and "diabetes". Important references from selected articles were also retrieved.
STUDY SELECTIONArticles regarding the role of BKCa channels in diabetic vascular complications and relevant mechanisms were selected.
RESULTSThe BKCa channels are abundantly expressed in vascular smooth cells and play an important role in regulation of vascular tone. Multiple studies indicated that the expression and function of BKCa channels are altered by different mechanisms in diabetic vascular diseases such as coronary arterial disease, cerebral arterial disease, and diabetic retinopathy.
CONCLUSIONBKCa channels may play an important role in diabetic vascular complications and may be an effective therapeutic target for relieving and reducing the burden of diabetic vascular complications.
