The clinical features and prognosis of radiotherapy associated sarcoma (RAS) following radiotherapy for nasopharyngeal carcinoma
10.3760/cma.j.issn.1673-0860.2014.11.016
- VernacularTitle:鼻咽癌放疗相关肉瘤的临床诊治和预后分析
- Author:
Shengye WANG
1
;
Minghua GE
;
Kejing WANG
;
Jianlin LOU
;
Xiaozhong CHEN
Author Information
1. 浙江省肿瘤医院放疗科
- Keywords:
Nasopharyngeal neoplasms;
Sarcoma;
Radiotherapy;
Surgical procedures,operative;
Treatment outcome
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2014;49(11):955-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features and prognosis of radiotherapy associated sarcoma (RAS) in the head and neck following radiotherapy for nasopharyngeal carcinoma (NPC).Methods The clinicopathologic data,diagnosis,treatment and follow-up results of 11 patients with RAS diagnosed between January 1995 and December 2011 at Zhejiang Cancer Hospital were analyzed retrospectively.Among these patients,6 were males and 5 were females.Patients' ages ranged from 33 to 66 years (median 50 years).The latency period for development of the RAS was between 3 years and 23 years (median 7 years) after irradiation.Overall survival rate was calculated using the Kaplan-Meier method and Log rank test.Results All cases underwent surgery,of them 6 casesachieved radical resection3 cases left with microscopic positive resection margins and 2 caseshad palliative surgery.Among 11 patients,4 had resurgery after recurrence,including 1 case had repeated surgeries followed by chemotherapy and radioactive seed implantation.Follow-up time ranged from 2 to 102 months,andeight patients died The 2-year,3-year and 5-year cumulative survival rateswere 45.5％,30.3％ and 15.2％,respectively.The median survival time was 15 months.Surgical resection with clear margins achieved significantly better prognosis (P =0.04).Conclusions The incidence of RAS after radiation of NPC is generally low,but the treatment of RAS is very difficult,with poor prognosis.
